Prurigo nodularis is a disorder characterized by intensely itchy rashes or bumps on the skin. Although a relatively uncommon condition, it can interfere with the daily lives of those affected. Here, one may be tempted to scratch, but this can make the rash worse. However, recognizing the early signs can help one get timely treatment to relieve the itching. So, one should keep an eye out for the following early signs of prurigo nodularis: Persistent itching Persistent itching is the key sign of prurigo nodularis. This itch is often described as an intense, insatiable, and relentless sensation. The itching can interfere with the ability to carry out daily activities, being a constant source of discomfort. Those with prurigo nodularis also find it difficult to resist the urge to scratch, which ultimately worsens the condition. Small bumps As prurigo nodularis progresses, small, raised bumps or nodules start to appear on the skin surface. These nodules can vary in size, from a few millimeters to several centimeters in diameter. They often feel firm to the touch and can be rough or scaly. Initially, these nodules may appear slightly discolored or flesh-toned, but they can turn reddish-brown or even dark brown over time.

Huntington’s disease is a genetic, neurodegenerative condition characterized by emotional, cognitive, and motor symptoms. The course of the disease involves a gradual development of involuntary jerking muscle movements and a progressive decline in memory and cognitive function. It shows symptoms such as uncontrolled movements and mental instability. Huntington’s disease (HD) is a genetic disorder inherited from a parent and is commonly divided into five stages of disease progression. So, let’s learn more about each stage. Stage 1: Preclinical stage People in the initial stage of Huntington’s disease may develop mild symptoms. While they may exhibit signs of a neurodegenerative disorder, the doctor might not diagnose the individual with Huntington’s disease. The symptoms of HD usually begin between 40 and 60 years of life. However, it may also appear as two years of age or as late as 80 years. In the early stages, damage to brain cells may cause symptoms such as: Involuntary twitching in the toes, fingers, or face Poor coordination May struggle to concentrate or solve problems Irritability Loss of inhibitions Depression Issues with complex movements Once these symptoms appear, a patient is diagnosed to be in the active stages of HD. It may take about eight years to pass from this stage to the next.

Leukemia is a type of cancer in which the body’s blood-forming tissues grow out of control. It has several subtypes, such as acute myeloid leukemia, lymphoblastic leukemia, and chronic lymphocytic leukemia. Like many cancers, leukemia is relatively treatable in its initial stages. Hence, individuals must diagnose it early. One way to detect this condition quickly is to look for its early signs and symptoms. Here are a few common signs of leukemia: Fever Leukemia tends to affect nearly every organ, including the immune system. When one’s immunity is compromised, it results in frequent bouts of fever and raised body temperature. Consequently, a person with this condition may experience night sweats on a daily basis. Sometimes, fever is a side effect of treatments used for managing leukemia. Muscle and joint pain Besides fever, individuals with early-stage leukemia may experience persistent pain in their muscles and joints. If the pain increases and leads to tenderness in the affected areas, it is a clear indicator of this cancer. Such symptoms tend to be felt more than seen. If untreated, the progressive pain can cause rapid organ damage. All these factors bring about noticeable muscle loss. Fatigue Since leukemia is directly associated with the blood cells, it causes circulation issues.

Itchy skin or pruritus is a sensation most people experience at some point. It is generally harmless and often annoying. However, if itchy skin persists continuously over a long period, it may indicate an underlying health condition. Also, if the itching occurs over the same body area and does not go away with simple remedies, one must consult their primary care doctor for a proper diagnosis. Here are some common signs of itchy skin that may require attention. Dry skin Dry skin is one of the most common causes of itching. When the skin cells lose hydration, the top layer becomes dry and flaky, which leads to irritation and repeated itching to get relief. Dryness can occur due to cold weather or low humidity. Excessive bathing, frequent showering with hot water, and using harsh soaps may also cause the skin to lose its natural hydration, leading to itchiness. Rash or redness Another common sign of itchy skin is when rashes develop over the affected areas. There can be redness as well, which results from inflammation. These rashes and red patches will vary in shape and size. These are usually areas of intense itching that worsen unless treated properly. Such rashes may develop due to allergic reactions, contact dermatitis, insect bites, or infection.

Sickle cell anemia is a genetic blood disorder characterized by abnormal, crescent-shaped red blood cells. It is caused by a specific genetic mutation that alters the structure of hemoglobin, the protein responsible for carrying oxygen in red blood cells. According to the World Health Organization, approximately 300,000 infants worldwide are born with sickle cell anemia yearly. These misshapen cells have difficulty passing through small blood vessels, leading to reduced oxygen delivery to tissues and organs. Causes of sickle cell anemia Sickle cell anemia, a genetic blood disorder, has its origins in specific genetic mutations. Understanding these mutations is essential for comprehending the condition’s causes. Genetic inheritance Sickle cell anemia is primarily a hereditary condition rooted in the inheritance of specific genetic mutations. A unique genetic combination occurs when both parents carry an abnormal hemoglobin S (HbS) gene. In this scenario, there’s a 25% chance that their child will inherit two copies of the HbS gene, leading to sickle cell anemia. The sickle cell trait The sickle cell trait comes into play when an individual inherits one HbS gene and one normal hemoglobin gene. Carriers of this trait typically do not experience severe symptoms associated with full-blown sickle cell anemia. However, they can pass this trait on to their children, making it a crucial consideration for family planning and genetic counseling.

A healthy immune system is responsible for keeping the body safe from foreign viruses and bacteria that attack the healthy cells in the body. In this manner, it plays a huge role in warding off any infections or diseases. However, some factors can weaken the immune system over time, including unhealthy lifestyle choices, environmental factors, and genetic factors. Thus, here are some signs and symptoms to look out for that indicate a weak immune system. Frequent illnesses This is a very common symptom in anyone with a poor immune system. One may catch colds easily, and the symptoms that usually go away in a week last for longer. These individuals are also susceptible to getting food poisoning easily, which may take more than a couple of days to get treated. There are some barrier responses from the immune system which usually helps keep illnesses in check, and this includes: Cough reflex, which helps in expelling any foreign object which suddenly causes irritation. Stomach acid, which helps in killing the microbes which can enter the body through the food and drinks consumed. Mucus production, which helps in trapping bacteria and any other small particles which can cause irritation or cause infection in the body.